Systemic treatment of acute myeloid leukemia (AML) /

While the intent in the treatment of relapsed or refractory AML is to allow subsequent transplant for responding patients, the decisions regarding transplant eligibility and procedures are beyond the scope of this document. [...] The most recent are the NNCN guideline (10), the Canadian consensus guideline for older patients (24), and the European Society for Medical Oncology (ESMO) guideline for diagnosis, treatment, and follow-up (25). [...] The American Society of Hematology and the College of American Pathologists are jointly preparing a guideline for the initial work-up of acute leukemia ( ). [...] Interpretation of Evidence for Recommendation 1 The Working Group concluded there was no evidence to suggest that other treatments were better than standard treatment with AraC plus an anthracycline, and that the beneficial and adverse effects of DNR, IDA, and MTZ were comparable; any of these is an acceptable choice. [...] Interpretation of Evidence for Recommendation 6 Additional cycles of consolidation increase the cost and the incidence of adverse events (including death) and this must be balanced with any survival benefit.