The use of leucovorin in colorectal cancer /

The development research of LV was in the context of bolus 5-FU delivery. [...] The results of this search can be seen in Appendix A. Only the National Comprehensive Cancer Network (NCCN), the Spanish consensus guideline, the National Health and Medical Research Council of Australia and BC Cancer Agency recommended dosages with the recommendations in their guidelines. [...] The Medical Research Council of Australia recommends the bolus Mayo regimen of 5-FU 425 mg/m2 plus LV 20 mg/m2 and the bolus Roswell Park regimen of 5-FU 500 to 600 mg/m2 plus LV 500 mg/m2 (6). [...] The list of trials that were part of the guideline and their included dosages are included as part of the table (9). [...] N=37, 43%; p=0.001 LV 20 mg/m2 followed by 5-FU 370 mg/m2, N=70 After the first 100 pts, the dose of 5-FU was Only pts with measureable disease were increased to 425 mg/m2 in the low-dose LV group included after the toxicity was analyzed.