The mandate of the Medical Advisory Secretariat is to provide evidence-based policy advice on the coordinated uptake of health services and new health technologies in Ontario to the Ministry of Health and Long-Term Care and to the healthcare system. [...] The duration of the procedure may be between 1 and 1.5 hours, with about 15 minutes for the CTA and the remaining time for the preparation of the patient. [...] Research Questions 1. How does the accuracy of CTA compare to the more invasive CA in the diagnosis of CAD in symptomatic patients at intermediate risk of the disease? [...] The variation in the prevalence of CAD, accompanied with differences in the proportion of calcification, likely affected the specificity directly and the sensitivity indirectly across studies. [...] Available from: Objective of Analysis The objective of this report is to determine the accuracy of 64-slice computed tomographic angiography (CTA) compared to the more invasive option of coronary angiography (CA) in the diagnosis of coronary artery disease (CAD) in stable (non-emergent) symptomatic patients.