Canadian Centre on Substance Use and Addiction Page 1 Substance Use Trends: Medetomidine Key Trends and Take-Aways Medetomidine detection first increased sharply in the unregulated supply in Ontario and Quebec in early 2024, and more recently in British Columbia. [...] Healthcare professionals, service providers and people who use drugs need to know about the strong sedative effects of medetomidine and the complications it creates for reversing drug poisonings (refer to the resource list at the end of this newsletter). [...] The proportion of expected fentanyl samples containing medetomidine increased from 4% in December 2023 to a peak of 27% in May 2024 and was 16% in July 2024. [...] A comprehensive response to the presence of medetomidine in the drug supply includes addressing the unpredictability and toxicity of the supply more broadly. [...] Disclaimer: While every effort has been made to identify and compile the best and most reliable information available on the topic, the nature of the newsletter is such that CCSA cannot confirm the validity of all information included or acquired from the links provided.
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