cover image: Lambda-Cyhalothrin Used as an Insecticide in Agriculture Study of Biomarker Toxicokinetics to Monitor

20.500.12592/3vnxh3

Lambda-Cyhalothrin Used as an Insecticide in Agriculture Study of Biomarker Toxicokinetics to Monitor

30 Jul 2021

Based on the approach applied in the last project, the general objective of this research project was to fill the gap in knowledge of the toxicokinetics of the biomarkers of exposure to lambda- cyhalothrin in humans in order to better interpret biomonitoring data and better assess the risks for exposed workers. [...] 4.1.4 Processing of samples and laboratory analyses The samples of plasma and urine were processed with a method previously developed in the research team’s laboratory to measure the metabolites of permethrin and cypermethrin, but with certain adjustments to measure the metabolites of lambda-cyhalothrin and to take account of the fact that the dose administered was lower than in the previous study. [...] Mathematically, the model specific to lambda-cyhalothrin reflects the essential determinants of the temporal evolution of the parent product and its metabolites in the human body and in the excreta. [...] For example, a first estimate of the value of the parameter kSB (transfer of the parent compound from the storage compartment to the blood) was made based on the slope of the last time points of the urinary profile of metabolites on a log-linear graph. [...] For the lunch break, the reconstruction presupposed that the worker washed the exposed skin area, which removed almost all of the product on the skin (approximately 99.5%); thus, for oral exposure, the scenario considered a hypothesis whereby the worker ingested a dose corresponding to 0.5% of the amounts accumulated on the skin during the 7-hour period following the start of the shift.
Pages
75
Published in
Canada

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