A young adult with first-episode psychosis: when to consider anti–N-methyl-D-aspartate receptor encephalitis

This is because while neurologic signs and symptoms in all patients with first-episode the frequency of anti-NMDAR encephalitis in patients with ovar- psychosis, the presence of which should lead to consideration of ian teratoma is about 1%, it is the most commonly detected anti-NMDAR encephalitis. [...] encephalitis confirmed a high frequency of EEG abnormalities, with the most common finding being diffuse and generalized slowing, indicative of encephalopathy.7 A normal EEG is thus atypical for anti-NMDAR encephalitis and reduces the likelihood of the disease. [...] With regard to false positives, a literature review of anti-NMDAR testing in first-episode psychosis showed a serum Diagnosis can also be made in the presence of 3 of the above groups of symptoms, accompanied by a systemic teratoma. [...] positivity rate of 3% across publications, often among patients Definite anti-NMDAR encephalitis who did not have distinct features of anti-NMDAR encephalitis and who did not have confirmatory CSF testing for anti-NMDAR per- Diagnosis can be made in the presence of 1 or more of the 6 major groups of symptoms and immunoglobulin G antibodies formed, highlighting the potential for false-positive seru. [...] Without these factors, the Antibody Testing for Neuro-I nflammatory Diseases, and receives yield from anti-NMDAR testing is low; we ordered the test in our support from the Opportunities Fund of the Academic Health Sciences Centre Alternative Funding Plan of the Academic Medical patient because of the association between ovarian teratoma and Organiza tion of Southwestern Ontario.