The ability of marine organisms to grow, survive, and reproduce in the face of OAH is partly dependent on the number, intensity, and interactions of other, non-OAH stresses they encounter, such as physical disturbances to nearshore habitats, warming temperatures, toxic contaminants, biological invasion, and harvest. [...] West Coast managers should inventory the co-location of protected areas and areas genetic tolerances to vulnerable to OAH to assess the number of locations they presently have in the two categories. [...] West Coast managers should facilitate the establishment of a working group of scientists and managers from relevant sectors to engage in joint fact-finding about the potential risks, benefits, and costs of active genetic intervention, such as through the selection, manipulation, and/or translocation of genetic varieties as a strategy for enhancing the persistence of species in mariculture settings [...] OA research is still in its infancy, with 75% of all acidification science studies published in the last five years, and only a handful of studies to date that have addressed the combined effects of OA and hypoxia, or OA and temperature, or OA and any other stressor. [...] Thus, the West Coast can and should serve both as a harbinger of OA’s impacts worldwide and as a case science approach is study on how to develop a highly effective, region-specific science strategy for reducing the threat of OA on the West Coast and other regions of North America.