The Canadian Antimicrobial Resistance Surveillance System (CARSS) is an essential component of this work and has been established by the Public Health Agency of Canada (the Agency) to strengthen the coordination and integration of antimicrobial resistance (AMR) and antimicrobial use (AMU) activities and information in Canada. [...] To better understand the magnitude and impact of AMR in Canada and to address the threat it poses, the Agency must adapt its surveillance approach so that more comprehensive information is available to inform public health decision-making and implementation of interventions to combat AMR. [...] CARSS will also provide leadership on AMR/AMU surveillance, inform and direct the expansion of surveillance activities to areas of greatest need and provide useful and relevant information to stakeholders and the public in support of antimicrobial stewardship interventions to protect the health of Canadians. [...] The Agency seeks the expertise of infectious disease physicians, family physicians and pharmacists through the Antimicrobial Use Working Group to assist in the interpretation and development of the Human Antimicrobial Use Report.2 This group was consulted on how they would cluster antimicrobials to treat Gram-negative and Gram-positive infections in the hospital setting (Table 1). [...] MG OF ANTIMICROBIAL ADJUSTED FOR POPULATIONS AND WEIGHTS 18 CANADIAN ANTIMICROBIAL RESISTANCE SURVEILLANCE SYSTEM—REPORT 2015 Because the same or similar antimicrobials are used in humans and animals, AMU in both sectors contributes to the emergence and spread of resistance in bacteria causing human infections.