Therapeutic guidelines : Antiretroviral (ARV) treatment of adult HIV infection

Since 1996, the guidelines have been generally consistent with those published by the International Antiviral Society–USA (formerly known as the International AIDS Society– USA) Panel.6 However, the reader should be aware that the use of antiretroviral drugs for the treatment of HIV infection within the BC-CfE programs is exclusively guided by the 2013 Guidelines as outlined here. [...] HIV increases the risk of liver-related morbidity and mortality in per- sons also infected with HBV.44 Furthermore, the ability to treat both infections with the same medications provides a compelling argument for the concomitant treatment of all HIV and HBV co-infected persons. [...] If TDF is necessary in patients with eGFR <50 mL/min, for example in the setting of HBV coinfection, the dosage should be adjusted according to the package insert,64 with the guidance of the St. [...] ATV/r and LPV/r have each been associ- THERAPEUTIC GUIDELINES FOR ARV TREATMENT OF ADULT HIV INFECTION 13 ated in cohort studies with loss of renal function, either in the setting of concomitant tenofovir59 or independent of it.60 62 The clinical significance of this finding remains to be elucidated. [...] Increasing attention has been focused on the monitoring of and interventions to improve ART adher- ence and in the rates of engagement of HIV-infected patients in the cascade of care.