• Dementia is a major public health concern of the 21st century and one of the leading causes of morbidity and mortality in aging population • Alzheimer’s disease (AD) is the most common form of dementia that attributes to 60-80% (2/3) of all dementia cases occur over the age of 65 years UNDERSTANDING ALZHEIMER'S DISEASE Neurodegenerative Disease: Most Common Form of Dementia: Typical Onset: Early. [...] Comparison of plasma pTau181 between Aβ- and Aβ+ (in HC, MCI and AD at timepoint T1) and between HC, MCI and AD at three follow-up timepoints (T1, T2 and T3) Comparison of plasma GFAP between Aβ- and Aβ+ (in HC, MCI and AD at timepoint T1) and between HC, MCI and AD at three follow-up timepoints (T1, T2 and T3) Comparison of plasma NFL between Aβ- and Aβ+ (in HC, MCI and AD at timepoint T1) and be. [...] Australia’s Growing Dementia Problem 2nd leading cause of death of Australians Leading cause of death in Australian women • Currently (2022), there are 487,500 people living with dementia in Australia, and it’s estimated that almost 1.6 million people are involved in the care of these people • The number of people with dementia is expected to increase to 1,076,000 by 2058 (Dementia.org.au/statisti. [...] The FINGER STUDY The Finland FINGER (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability) study showed that the combination of regular exercise, brain training exercises, adherence to the MIND diet, and regular monitoring of vascular risk factors significantly benefits cognition. [...] site of damage/infection) but can involve the lining of blood vessels and many internal organs and systems • Neuroinflammation: Specifically, inflammation of the central nervous system including the brain, and in the case of AD is a response to the build up Aβ, a small protein that is toxic if not removed It is conceivable that the protective role of MeDi against cognitive decline is mediated by t.
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Table of Contents
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- Slide 34: Current Gold Standard Markers for AD 34
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- Slide 58: Australia’s Growing Dementia Problem 58
- Slide 59: Background To The AU-ARROW Study 59
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- Slide 61: AU-ARROW Clinical Study Design 61
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