Practice | Five things to know about ... - Primary ovarian insufficiency 1

doi: 10.1503/cmaj.221712 1 Primary ovarian insufficiency (POI) affects 1% of P atients with hypoestrogenic symptoms should be reproductive-aged women 5 offered hormone therapy, which also reduces the In POI, ovarian follicles become depleted or dysfunctional risk of cardiovascular events and hip fracture in people younger than 40 years. [...] 3 Genetic and laboratory investigations can identify Obstet Gynecol 2017;129:e134-41.some causes of POI Patients should be offered genetic testing for Fragile-X and karyotyping to rule out Turner Syndrome and presence of Competing interests: Marie Christakis and Lindsay Shirreff sit Y-chromosome material.2 Autoimmune investigations on the medical advisory board of the Menopause Foundation of inclu. [...] Affiliations: Department of Obstetrics and Gynaecology (Brent, Christakis, Shirreff), University of Toronto; Department of 4 P atients should be counselled on increased risks of Obstetrics and Gynecology (Christakis), St. [...] Michael’s Hospital; infertility, osteoporosis and cardiovascular disease Department of Obstetrics and Gynaecology (Shirreff), Mount The rate of spontaneous pregnancy is low (5%).3 Patients Sinai Hospital, Toronto, Ont. [...] with POI respond poorly to ovulation induction and ovarian Content licence: This is an Open Access article distributed in stimulation, and often require egg or embryo donation.2 accordance with the terms of the Creative Commons Attribution Patients with newly diagnosed POI should have baseline (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that.