221802-res-1-at

The association of sensitivity and specificity with disease prevalence: analysis of 6909 studies of diagnostic test accuracy. [...] Fixed effects included disease prevalence categorized as quartiles based on the distribution within a meta-analysis (≤25 percentile as reference, 25-50 percentile, 50-75 percentile, and above) or arbitrary prevalence cutoffs (25%, 50%, 75%, and 100%), adjusting for the target condition category (collapsed into 5 categories based on the discipline or specialty to facilitate analysis: internal medic. [...] The association of sensitivity and specificity with disease prevalence: analysis of 6909 studies of diagnostic test accuracy. [...] The association of sensitivity and specificity with disease prevalence: analysis of 6909 studies of diagnostic test accuracy. [...] Appendix: Analysis Codes Primary analysis: Secondary analysis: Sensitivity analysis (adding the slope of prevalence as a random effect).