Predictors of fatal and nonfatal overdose after prescription of opioids for chronic pain: a systematic review and meta-analysis of observational studies Research Predictors of fatal and nonfatal overdose after prescription of opioids for chronic pain: a systematic review and meta-analysis of observational studies Li Wang PhD, Patrick J. [...] including lack of statistical pooling of measures of associa We assessed risk of bias by evaluating the representativeness tion,12,13,15–17 inadequate assessment of risk of bias,12,15,16 outdated of the study population, validity of outcome assessment, loss to searches,12–17 a focus on select populations such as older adults12 follow up and whether predictive models were adjusted, at min or peop. [...] Given the number of predictors considered in our review, we Predictors of fatal and nonfatal overdose focused our main presentation of findings on predictors that Moderate certainty evidence showed the pooled prevalence of showed large relative associations (OR ≥ 2 or ≤ 0.5) with opioid fatal opioid overdose after prescription for chronic pain was 1.3 overdose supported by moderate or high certai. [...] Prevalence of chronic pain and high the risk of opioid overdose among people living with chronic pain. [...] As such, and overdose: a systematic review and meta analysis of unintentional pre they are at low risk of bias for ascertainment of exposure.107 scription opioid overdose.
- Pages
- 13
- Published in
- Canada
