230237-guide-1-at

Current oncology (Toronto, Ont.) 2021;28(3):1728-1743 1.8 – Equity outcomes: screening education and opportunistic screening PICO Population: Indigenous Populations in Canada Intervention: Equity outcomes - screening education and opportunistic screening Comparator: N/A Summary of findings table Study results and Absolute effect Certainty of the Plain language Outcome measurements estimates Eviden. [...] Cervical Cancer Screening Evidence to decision Benefits and harms Substantial net benefits of the recommended alternative Screening for cervical cancer increases early detection of cervical cancer across all screening methods. [...] In round 1 of screening, CIN3+ detection rates ranged from 0.3% to 0.8% for primary hrHPV CIN3+ detection rates screening were consistently (intervention) higher in the hrHPV compared with 0.1% to Based on data from group across all 6 0.4% for cytology 232464 trials reporting on CIN3+ detection (control), with RRs participants in 6 one round of rate9 10 ranging from 1.61 (95% - studies screening. [...] In Round 1 of screening, false- positive rates ranged from 6.6% to 7.4% for False-positive rates primary hrHPV Based on data from were consistently screening 175543 higher in the hrHPV (intervention) - False positive rate11 participants in 2 group across both 12 compared with 2.6% to studies trials reporting on 6.5% for cytology Follow up 5-7 years one round of (control). [...] One trial found False-negative rate Based on data from invasive cervical cancer for invasive cervical False negative 252621 13 among screen-negative cancer was slightly rate participants in 2 14 women in 0.01% - higher in the cytology studies (5/57,135) of the group in 1 of the 2 Follow up 3-5 years hrHPV group trials reporting on 13 mailto:cmajgroup@cmaj.ca (intervention) and one round of 0.003%.