Remdesivir for the Treatment of COVID-19 in the Outpatient Setting

06 / 132 Remdesivir for the Treatment of COVID-19 in the Outpatient Setting Introduction and Rationale Objectives The objective is to evaluate the efficacy, effectiveness, and safety of remdesivir for the treatment of COVID-19 in nonhospitalized adults (outpatients). [...] Clinical heterogeneity was assessed across studies by documenting and reviewing the variation of the characteristics of the study patients by severity of condition, demographics, and setting; the interventions in the implementation (e.g., dose or intensity), experience of practitioners, and nature of control (placebo, none, standard of care); and in the outcomes by measurement methods, event defin. [...] 17 / 132 Remdesivir for the Treatment of COVID-19 in the Outpatient Setting Results of Clinical Evaluation Figure 1 PRISMA Flow Chart of Selected Reports 18 / 132 Remdesivir for the Treatment of COVID-19 in the Outpatient Setting Results of Clinical Evaluation Study Characteristics The characteristics of the studies of interest for this report are summarized in Table 3, Table 4, Table 5, and Table. [...] 21 / 132 Remdesivir for the Treatment of COVID-19 in the Outpatient Setting Results of Clinical Evaluation The trial protocol was to enrol a total of 1,264 patients, allowing for sample size re-estimation at the interim analysis after approximately 50% of participants had completed the day 28 visit because of uncertainties about the event rates for hospitalization and death rates in the placebo ar. [...] 49 / 132 Remdesivir for the Treatment of COVID-19 in the Outpatient Setting Results of Clinical Evaluation Data Analysis and Synthesis Randomized Controlled Trial Findings Suggest The results reported on the outcomes of interest in the randomized Remdesivir lowers the risk controlled trial, as well as additional results calculated based on the of COVID-19–related reported study results, are provid.