Use of Oncotype DX for guiding adjuvant chemotherapy decisions in early stage invasive breast cancer patients in Alberta

Table 1: Staging of Breast Cancer Stage Description There are two kinds of stage 0 breast cancer: 0 1. Ductal carcinoma in situ (DCIS): Abnormal cells are in the lining of a milk duct and have not spread outside the duct 2. Lobular carcinoma in situ (LCIS): Abnormal cells are in the lining of a lobule 1 Tumour is 2 cm or smaller and the cancer has not spread outside the breast 2 Tumour is 2 to 5 c [...] Often, these features, along with the patient’s individual characteristics and risk profile are used to assess the severity 18 of the cancer and the probability of recurrence. [...] Given the quality and comprehensive nature of the NICE assessment, the current report incorporates the evidence from the NICE report replicating the literature search to update the evidence. [...] The weight of each study, calculated based on sample size, carries in the pooled estimate is represented by the size of the box surrounding the point estimate. [...] Of the selected studies, 10 reported the effect of Oncotype DX risk score on chemotherapy treatment decisions, and 4 reported the utility of Oncotype DX in predicting benefit from chemotherapy.