Risk of cancer of the colon and rectum in firemen : Chemical substances and biological agents

R-516 Risk of Cancer of the Colon and Rectum in Firemen Disclaimer Douglas McGregor The IRSST makes no guarantee Consultant regarding the accuracy, reliability or completeness of the information contained in this document. [...] Most of the tumours of the large intestine are of epithelial origin and are considered malignant when the tumour penetrates the muscularis mucosae into the submucosa (Hamilton et al., 2000). [...] Temporal changes in the incidence of cancers of the colon and cancers of the rectum differ. [...] Within the USA, the incidence of adenocarcinoma of the colon increased by about 18% during the period from 1973 to 1988 while the incidence of rectal adenocarcinoma and mucinonous adenocarcinoma in the colon remained relatively constant in this period (Thomas & Sobin, 1995). [...] From the point of view of measures of exposure, length of the historical cohort and length of follow-up, this was a particularly valuable study.