Coherent Identifier About this item: 20.500.12592/9sj985

Harms of prostate-specific antigen (PSA) screening in prostate cancer /




A Rapid Review May 2015 Harms of Prostate-Specific Antigen (PSA) Screening in Prostate Cancer JENNIFER FERGENBAUM CONTEXT This rapid review examines the harms of prostate-specific antigen screening in prostate cancer to facilitate decisions regarding the benefits versus the harms of screening for prostate cancer. [...] A detailed review of the clinical effectiveness of PSA screening in prostate cancer has been recently completed.1 Clinical Need and Target Population PSA screening for prostate cancer is defined as a screening program for prostate cancer in asymptomatic men that incorporates one or more PSA measurements, with or without additional modalities such as digital rectal examination. [...] Literature Review Summary The details of the 3 systematic reviews included have been summarized in Appendix 2. The results by study and outcome (e.g., harms of PSA testing, harms of biopsy, overdiagnosis) are shown below in Tables 2 and 3. Since the evidence for the harms of PSA screening for prostate cancer were taken either from the screening group only or simulation study (e.g., overdiagnosis), [...] May 2015 Table A2: (cont’d) Detailed Summary of Included Systematic Reviews (N = 3) Author, Research Question Definition of Screening Methods Qualitative Summary of Harms Outcomes Year Djulbegovic In men without a history of Screening by testing for Systematic review Three centres-ERSPC Trial: reported no excess of mortality due to et al, 2010 prostate cancer, screening prostate specific antigen w



health science and technology research cancer medical screening medical research medicine health care mass screening clinical medicine prostate-specific antigen prostatic neoplasms systematic review healthcare policy health treatment health sciences government health care medical specialties diseases and conditions prostate prostate cancer prostate specific antigen psa psa screening prostate cancer screening overdiagnosis