Harms of prostate-specific antigen (PSA) screening in prostate cancer /

A Rapid Review May 2015 Harms of Prostate-Specific Antigen (PSA) Screening in Prostate Cancer JENNIFER FERGENBAUM CONTEXT This rapid review examines the harms of prostate-specific antigen screening in prostate cancer to facilitate decisions regarding the benefits versus the harms of screening for prostate cancer. [...] A detailed review of the clinical effectiveness of PSA screening in prostate cancer has been recently completed.1 Clinical Need and Target Population PSA screening for prostate cancer is defined as a screening program for prostate cancer in asymptomatic men that incorporates one or more PSA measurements, with or without additional modalities such as digital rectal examination. [...] Literature Review Summary The details of the 3 systematic reviews included have been summarized in Appendix 2. The results by study and outcome (e.g., harms of PSA testing, harms of biopsy, overdiagnosis) are shown below in Tables 2 and 3. Since the evidence for the harms of PSA screening for prostate cancer were taken either from the screening group only or simulation study (e.g., overdiagnosis), [...] May 2015 Table A2: (cont’d) Detailed Summary of Included Systematic Reviews (N = 3) Author, Research Question Definition of Screening Methods Qualitative Summary of Harms Outcomes Year Djulbegovic In men without a history of Screening by testing for Systematic review Three centres-ERSPC Trial: reported no excess of mortality due to et al, 2010 prostate cancer, screening prostate specific antigen w